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When Dorothy and Toto were walking through a field of red poppies in the Wizard of Oz, they fell asleep quickly. Those who venture outside of Oz into the world of opium-derived drugs are likely to encounter demons much more dangerous than sleepiness and flying monkeys.
Opiates are highly potent and efficient painkillers when used for medicinal purposes. However, opiates and their variants, such as heroin, fentanyl, hydrocodone, morphine, oxycodone, and codeine, are highly addictive medications with potentially dangerous side effects. When administered, these medications can result in collapsed veins, skin abscesses, and massive scarring, as well as debilitating withdrawal symptoms and even death.
The word “narcotic” is derived from the Greek word “narkotikos,” which means “to numb,” and refers to a class of drugs that includes opium and its derivatives. Opium has been mentioned since 3,000 B.C., and its popularity for medicinal and recreational purposes resulted in a thriving trade between East and West. It was a major player in China’s so-called Opium Wars in 1839.
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Since ancient times, the manufacturing processes have remained largely unchanged. The content of the phenanthrene alkaloids morphine, codeine, and to a lesser degree thebaine has been greatly increased through selective breeding of the Papaver somniferum plant. In modern times, much of the thebaine used in the production of oxycodone, hydrocodone, hydromorphone, and other semisynthetic opiates comes from the extraction of Papaver orientale or Papaver bracteatum.
At least 17 discoveries of Papaver somniferum have been recorded from Neolithic settlements in Switzerland, Germany, and Spain, including the placement of large numbers of poppy seed capsules at a 4200 BC burial site (the Cueva de los Murciélagos, or “Bat Cave” in Spain). There have also been several reports of P. somniferum or P. setigerum being discovered in Bronze Age and Iron Age settlements.  The first recorded cultivation of opium poppies was by Sumerians in Mesopotamia around 3400 BC, who named the plant hul gil, or “joy plant.” (#13)  Tablets discovered in Nippur, a Sumerian spiritual center south of Baghdad, detailed the morning collection of poppy juice and its use in opium cultivation.  The Assyrians managed to cultivate the poppy in the Middle East, collecting the juice in the morning after scoring the pods with an iron scoop; they called the juice aratpa-pal, probably the root of Papaver. The Babylonians and Egyptians continued to produce opium.
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Opium is an opiate that has a major impact on human physiology and behavior. Opium was used by ancient priests as a powerful healing drug, and many medical texts, especially during the nineteenth century, referred to it as medicine. Opium was once widely used for medicinal purposes and was referred to as “God’s medicine.” Understanding the molecular mechanism of opium function within cells, on the other hand, is critical from both a pathophysiological and clinical standpoint. According to current research, opium can initiate cell death by activating apoptotic events, which then cause angiogenesis cascade pathways. The effects of opium on cell apoptosis and angiogenesis are investigated in this review article.
After smoking, a brown and shiny substance known as “burnt opium” is left behind, which is soluble in water and can be reused.
Addicts re-use burned opium by dissolving it in water and boiling it. The pulp is then produced by passing it through a strainer. Consumers reheat the pulp to produce “juice,” a thick, brown paste. This juice is more potent than morphine and can be taken orally or smoked.
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Opium is a narcotic substance made from the unripe seedpods of the opium poppy (Papaver somniferum), which belongs to the Papaveraceae family of plants. (Take a look at the poppy.) After the plant’s flower petals have dropped, the seed capsules of the poppy are slightly incised to acquire opium. When exposed to sunlight, the milky latex from the slit seedpods coagulates and changes color, turning into a gumlike brown mass. Raw opium can be ground into a powder, sold as lumps, cakes, or blocks, or processed further to produce morphine, codeine, and heroin derivatives. Opium and its derivatives are referred to as opiates. the drug opium Opium in its purest form. Fenderson, Erik
The pharmacologically active components of opium are its alkaloids, the most common of which, morphine, makes up about 10% of raw opium by weight. Papaverine and codeine, two other active alkaloids, are found in smaller amounts. Opium alkaloids are classified into two groups based on their chemical structure and action. Morphine, codeine, and thebaine, for example, are analgesic, narcotic, and potentially addictive agents that function on the central nervous system. Most opium alkaloids, including papaverine, noscapine (formerly known as narcotine), and the rest, function only to relax involuntary (smooth) muscles.